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Has anyone lowered their Abiraterone Dosage? To what effect?
Prostate Cancer | Last Active: Nov 17, 2023 | Replies (26)Comment receiving replies
Again, everybody, I am asking about a reduced dosage of abiraterone, not prednisone. I only included the prednisone in parentheses so readers would know I was also taking prednisone and so wouldn't bother recommending it.
samidh and shelby29, were your experiences with prednisone related to taking a reduced dosage of abiraterone (from the usual 1000mg)? If so, what were the effects you experienced from the *reduced* dosage, or were you originally prescribed the lower (less than 1000mg daily) dosage?
Replies to "Again, everybody, I am asking about a reduced dosage of abiraterone, not prednisone. I only included..."
To clarify, my dosage of Abiraterone has always remained at 1000mg. Only my Pred dosage was decreased from 10mg to 5mg, and with this revised dosage of Pred there was no appreciable difference that I could feel.
I have had your thought before. My theory would say you need higher dosage to knock down the high levels of psa/testosterone than would be required to maintain a low level. The object would be to limit adverse side effects and prolong efficacy of the drug before failure. Might be wishful thinking on my part but glad you brought it up for discussion. My observation is that there several bright minds in this group.
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I have the same question, after hearing Dr. Scholz and Dr. Moyer discuss this on a PCRI video. They said "a study" showed the equivalent efficacy of taking one-half the dosage of Abiraterone with a healthy breakfast. They chuckled that everyone is excited about the results--except the drug companies. So far I have not been able to find the study. (Parenthetically, it would be nice if it also meant one-half the dose of Prednisone.) I will message my P.A. at Mayo to see what they recommend.