I have been taking anastrazole for almost 5 years. I think my hair is thinner, but I’m not sure if that was the result of the hair loss from chemo, the fact that I have thin hair to begin with, and I’m older, or the Anastrozole. The bigger issue I’m having with the anastrozole is an almost total inability to lose weight. I don’t think I’ve gained any or if I have, I haven’t gained much, but any attempt to lose weight almost always fails. When I talked to the chemo doctor about it and explained that I was getting , for a 71-year-old woman, an extremely high amount of consistent exercise, was following a sensible diet, and still could not lose anything. His response was it is the Anastrozole. For some reason it causes fat cells to settle in adipose tissue rather than be burned off by activity.