Taking a Lower Dose of Tamoxifen?

Posted by vivi1 @vivi1, Oct 6, 2021

Given the risk of endometrial cancer from tamoxifen, which apparently increases with dosage, length of use, and the age of the patient, is anyone taking a lower dose in order to extend adherence and soften side effects?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

Here is some great questions and a few answers for us or…… maybe our daughter and granddaughters. There is two threads I am posting this podcast.
https://connect.mayoclinic.org/blog/podcasts/newsfeed-post/systemic-therapies-for-breast-cancer/

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I started on 20 mg Tamoxifen and was extremely concerned about endometrial cancer since my mother died of that. I’m very low risk 90/10 over 10years. But ER positive so I said I give it a try. After 7 months I went to 10mg on my own and feel way better.

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In 2012, my dosage after L mastectomy, was 20mg, which I took for 27 mo ( was to be for 5 years), but I had so much pain, muscular and joint, that I stopped taking it ! My hematologist disagreed, but said I’d probably had the benefit from it in 27 months. I’d already had 2 knees and 1 hip replaced, so I KNEW joint pain! @hjtkyhl

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@margewhite

I started on 20 mg Tamoxifen and was extremely concerned about endometrial cancer since my mother died of that. I’m very low risk 90/10 over 10years. But ER positive so I said I give it a try. After 7 months I went to 10mg on my own and feel way better.

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How are you doing so far with tamoxifen 10 mg?

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@margewhite

I started on 20 mg Tamoxifen and was extremely concerned about endometrial cancer since my mother died of that. I’m very low risk 90/10 over 10years. But ER positive so I said I give it a try. After 7 months I went to 10mg on my own and feel way better.

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What symptoms went away when you decreased from 20 to 10???

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yes. I am on 5 mg. no issues yet in 4 months.

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