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Undecided choice of drugs for Osteoporosis

Osteoporosis & Bone Health | Last Active: Sep 8 8:12am | Replies (393)

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@violetsteptoe

My endocrinologist days I can’t stop my Prolia shots after taking 4 doses in the last two years. I hear it can affect dental work (i.e. dental implants). Am I able to use something else. I took Fosamax for 5 yrs for osteoporosis but it did nothing. She said Prolia had helped me. What’s the answer, please?

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Replies to "My endocrinologist days I can’t stop my Prolia shots after taking 4 doses in the last..."

@violetsteptoe if Prolia is helping you, how long can you continue? Ask your dentist.pharmacist and endo. I have read you can be on it for years, even for life, and the rate of dental issues is low but your dentist or endo might be able to give details. (I have also read most jaw necrosis is among cancer patients on very high doses.)

It is very hard to get off Prolia. There is an abrupt loss of bone density and increase in fracture risk unless followed up by Reclast or another bisphosphonate (Reclast is best) and the timing is crucial. Keith McCormick's book "Great Bones" goes into this transition timing in detail. You can get it in the library or online.

If your bones are in serious condition, ask your doc about Evenity. I have read that Tymlos and Forteo are not good choices for bone-building after Prolia, that they don't work. But don't take my word for it, ask your doc!
Usually the sequence is Evenity then Prolia so I have no idea about the opposite. Evenity is new and my doc says they are lacking data.

Here is info on dental issues from the Prolia site:
Dental and jaw-related side effects
Although rare, it’s possible to have dental and jaw-related side effects from using Prolia.

Symptoms of dental and jaw-related side effects can include:

loosening of the teeth
jaw pain or numbness
mouth infections
One potential complication is jaw necrosis (death of jawbone tissue). This may cause teeth to become loose and need to be removed. According to the American Dental Association, the risk of jaw necrosis increases if denosumab, the active drug in Prolia, is used for more than 2 years.

What might help
Before you begin treatment with Prolia, your doctor should examine your mouth. They may recommend that you see a dentist before starting Prolia.

You should practice good oral hygiene while using Prolia, including brushing and flossing your teeth. This can help prevent dental and jaw-related side effects that Prolia might cause.

If you notice any symptoms of dental or jaw-related side effects while using Prolia, contact your doctor or dentist right away. You should also contact your doctor or dentist if you experience pain or slow healing following dental surgery.

Before you have any dental procedure, be sure to tell your dentist that you’re using Prolia.

I had severe constant leg cramps from Prolia. I stopped it. I’ve taken all the bone builders & nothing helped.
I’m done with medications. I walk & carrying cat litter boxes is my weight bearing exercises. All meds have side effects.