Does anyone know the meaning of these terms in my EGD report?

Posted by warrendog @warrendog, Nov 8, 2023

I had an EGD this week to review the status of my hiatal hernia and my continuing reflux. The doctor took a biopsy of a small polyp that appeared benign. The lab results came back as the following:
Gastric mucosa with xanthomatous changes ( CD68+, pankeratin-)
Does anyone know what these terms mean? I have a follow up appointment soon, but I’m very anxious to understand what these terms mean.

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@warrendog, I think lab results can be unnerving and make a person anxious. You might just want to give your doctor a call to ease your mind before your upcoming appointment. Not sure Dr. Google will make you feel any better trying to interpret the lab results. Here is some information on the CD68 protein:
https://www.mypathologyreport.ca/pathology-dictionary/cd68/

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In reply to @mikaylar "Ask Goggle." + (show)
@mikaylar

Ask Goggle.

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I tried. The answers are all in complicated scientific terms the average person can't understand.

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I googled it and this is what I found from the Cleveland Clinic:
An esophagogastoduodenoscopy, EGD for short, is a simple procedure to examine your upper GI tract. The test involves an endoscope, a lighted camera on the end of a tube, which is passed down your throat to visualize your esophagus, stomach and duodenum. It’s also called an upper endoscopy exam.
Hope that helps!
P

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@pkh3381

I googled it and this is what I found from the Cleveland Clinic:
An esophagogastoduodenoscopy, EGD for short, is a simple procedure to examine your upper GI tract. The test involves an endoscope, a lighted camera on the end of a tube, which is passed down your throat to visualize your esophagus, stomach and duodenum. It’s also called an upper endoscopy exam.
Hope that helps!
P

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This part I know. It’s the terms in the report that I don’t know

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warrendog @warrendog

Waiting for doctor appointment after reading a report is always a time of anxiety. Google can be a friend or enemy. I suggest you limit your research, just enough to ask questions.

As other suggested, your doctor can explain, but as far as a definition, the National Institute for Health has following definition:
What is a xanthoma of the gastric mucosa?
Xanthomas of the gastrointestinal system are tumor-like lesions that occur in the form of yellow to white, well demarcated mucosal nodules or plaques. Histologically, xanthomas consist of clusters of foamy histiocytes containing lipid.

CD68+ when google is very technical, my non-medical interpretation is it is a test for certain antibody and interpretation help with diagnose.

The most important question to doctor is does biopsy shows any sign of cancer and does xanthoma of the gastric mucosa increase chance of cancer.

Hopefully your dr appointment is soon so you can get your answers.

Laurie

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I suggest you get a follow up endoscopy in another 6-8 weeks to see if its improved or gotten worse.

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Warrendog, I fully understand your anxiety and worry. It appears to me that you have tiny deposits of fat in areas. That is what xanthelazmas are. I have two in the corners of each eye. No treatment needed. What is your cholesteral level?

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