Hi @nonobaddog My mom was diagnosed with stage 3B (possibly 3C) NSCLC in Feb. She had a tumor of 7cm in her lower left lobe and mets to mediastinum lymph nodes. She did 5 months of targeted therapy with Dabrafenib and Trametinib, since she has the BRAF 600E mutation. That shrank the tumor to 3cm in Aug. She just finished 30 sessions of proton beam therapy plus 6 weeks concurrent Carboplatin and Paclitaxel a week ago. That's the same treatment as you! My mom has Sjogren's Syndrome, so her oncologist is concerned that she might get peumonitis and don't recommend doing immunotherapy next. Instead, continuing with targeted therapy of Dabrafenib and Trametinib was recommended. I am really curious if you have any adverse side effect with the immunotherapy of Durvalumab. Could you comment?