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Morning misery: Is prednisone effective 24 hrs? PMR and hands

Polymyalgia Rheumatica (PMR) | Last Active: Dec 15, 2023 | Replies (58)
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@art43

You may want to take a look at the potential downside of split doses versus increasing the single morning dose as regards the possibility of unnecessarily provoking adrenal insufficiency with a split dose. Lots of pros and cons. Good luck !

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Replies to "You may want to take a look at the potential downside of split doses versus increasing..."
DadCue | @dadcue | Nov 4, 2023

Taking prednisone in excess of 5 mg per day increases the risk of secondary adrenal insufficiency.
https://www.endocrine-abstracts.org/ea/0037/ea0037ep46
The risk increases in proportion to dose and duration of treatment with prednisone. For people with PMR who are treated with long term prednisone --- adrenal insufficiency is almost a given.
https://www.endocrine-abstracts.org/ea/0056/ea0056p44

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