Hello @donna2023, welcome to Mayo Clinic Connect. It sounds like you have had a rough go with your flagyl regimen in particular. I'd like to invite a few members who have also discussed diverticulitis and flagyl to share some of their experiences with the medication. @bbarbiee, @frane1939, @vjs, and @lisag03 have all used flagyl for a digestive health issue.

@donna2023, you may also find the following discussion of interest, "Diverticulitis and persistent pain" - https://connect.mayoclinic.org/discussion/diverticulitis-and-persistent-pain/.

@donna2023, have you discussed your struggles with the flagyl part of your medication regimen with the provider who prescribed it? Have they offered any alternatives knowing you are unable to finish the full 7 day regimen?

I had diverticulitis for several years. Yes, Cipro and flagyl. I could not take flagyl. About 4 years ago I was prescribed due to a flare After one pill the bottom of my foot started to burn , itch and swell. I couldn’t be for sure if it was the flagyl; however, 3 weeks ago I was prepping for a colon resection and was prescribed flagyl as well as other antibiotics to take Again, this happened to my foot. At that point I realized it was the flagyl that had done this a few years ago. I told my surgeon on the morning of and ask her if she was planning on giving me more during surgery. She immediately said she had other options other than flagyl. I’m 3 weeks out from resection. I’m glad I had the surgery. Path report showed abscess and at some point I had a perforation.
I know your feeling of hurting with these issues and the dread of the meds. My flares were numerous in the last year plus I am a liver transplant so I have to be cautious with all aspects of health

I am very interested to listen to both of your stories. I have had GERD for years, doing ok, then suddenly diagnosed with this thing called LPR. I loved my previous GI doc, as he always spoke to me like I have a brain, but unfortunately has retired. I have a large Left Inguinal hernia, and have as he had told me, diverticulosis. I have in the past 2yrs had 3 terrible episodes that were very scary, and painful, but not sure of what was happening. First one, doubled over with pain,low grade ttemp, and vomiting. I thought it was eating something "spoiled" Could not eat for sweveral days, but little by little started to eat. Second one no apparent temp, but terrible pain and bloating like I was hiding a basketball in my PJ's. Also vomiting, but no stool for 3 days. The last one was waking up at 130 am so nauseated and abd. bloating, I ran to the BR and broke out in a cold sweat, but could not vomit, and no stool. I had trouble breathing because I was wretching continuously. For a moment I thought I was going to die. Same recovery--could not eat for days, but eventually I began with toast and oatmeal. Saw the PA at a new office, and she said I was probably just constipated, so up my fiber. Also, that I should have gone into ER for an X-ray. Does this sound like Diverticulitis ? I do not look forward to another attack like this.

Thankyou all so much for sharing. Now I am pretty convinced that this was a bout of diverticulitis. My problem is that I am 76yr.old, with no family near by, and I would have to drive myself to an ER which is quite far away. If during the day, I may or may not be able to do this. But I will have to see what the future brings. And yes I am concentrating daily on fiber.

Wishing you good luck.