If we're all being honest regarding the uterine/endometrial biopsy... I am in my 40's, had 2 children and was on my tail end of my period and still can honestly say it was painful. I took 800mg ibuprofen 45 minutes before the procedure and still squeezed the hell out of my husband's hand. If he was not there, I don't know what I would have been grabbing onto. I did deep breathing to try and relax the uterus, but it that did not help. It felt like something was ripping out my insides, as the pain was so intense. My OB did 2 pipelles, so 10 seconds of pure agony x 2. To make matters worse, I had a Mirena IUD placed immediately afterward, so a uterine sound had to go up there and then the Mirena pipette equivalent. My body was shaky and I needed to lay on the table after the procedures, when I got up, my legs were unstable. More than 18 hours later my uterus is still angry and cramping in my abdominal area and back and I can feel pain where the biopsies were taken.