Colleen.. thank's for all you do assisting this group. I wish there was more info. on 'drug holidays' or 'intermittent use of ADT'. I know there was one study in Japan I think; but not U.S. .. Also no discussion on say an older guy (over 75) taking Orgovyx ... as ADT alone... without surgery or radiation. IE: QOL concern given it seems longevity is about the same (difficult statistics as once someone hits 80, well how many years left won't vary much regardless of treatment). I'm wonder if 'ADT only' is a wise course; AND is there info. on after successful year of treatment; PSA pops up a bit (say from .1 to 3. ..) will another few months of restarted treatment be sufficient and then 'do nothing' beyond. May not be what supports the clinics; but wonder if it's a reasonable choice (and I'm referring to 'localized' PC, Gleason Score 8; but not metastasized. I have conflicting views from doctors; of 'radiation' (but I have a pacemaker); 'just the ADT and restart'; to 'you had a course; now enjoy life and don't think about it. I realize there's no perfect answer; open to reflections on this topic...thanks! I appreciate you! (Lurking so far; first post ever.)