I find your question very interesting since I've had very Bad low back and sciatica for the last few years and have recently developed neuropathy Pain and small area of my left foot above my Big and second toe. As an retired RN that used to work neural intensive care And knowing that the dermatone for spinal nerves L5 and S1 meet at that juncture, I assumed my neuropathy was related to that but nobody else seems to think so... Even the neurosurgeon. And now I'm starting to get a few mild symptoms on my right foot. I am not diabetic so my neuropathy is definitely not related to that issue. However I am 80 and Is overweight which doesn't help the situation any and because of my sayatica and then a total knee replacement the last couple of years I have not been very active at all and I'm sure that has really reduced the circulation in my feet. Duloxetine Helped at first but I am now having breakthrough multiple times a day and I'm looking for other options to help with this. I've been doing quite a bit of research and there is some out there that talks about Ems therapy helping if your nerves aren't already dead which mine are still alive but in the dying stage so I am going to give this a try and have contacted Mayo about the Calmare therapy. However it is very expensive and you need to be near the place that is offering it or it gets even worse expense wise because of the needed travel. Don't know if this has been of much help but I do know that until things get better the only thing that helps the brake through pain is putting some ice packs on it which does stop the pain but then it also shuts down circulation in my foot which is not helpful in the long run either. So I feel kind of caught between the devil and the deep blue sea right now with trying to treat this but bought myself an Ems device as I notice that the Revitive Device that I bought long ago and should have been using for circulation seems to help some so I hope the EMS device does even a better job. I guess time will tell.