← Return to The Constant Cough Question

Discussion

The Constant Cough Question

MAC & Bronchiectasis | Last Active: Nov 9, 2023 | Replies (38)

Comment receiving replies
@cwal

I'm probably coming into this conversation late or missed something, but I don't understand how azithromycin (an antibiotic) would help with coughing?

Jump to this post


Replies to "I'm probably coming into this conversation late or missed something, but I don't understand how azithromycin..."

Right, AZ is not a cough suppressant but treats the MAC bacteria, pneumonia, etc. AZ IV has saved my life 2 times.

I copied this from a medical journal article written in 2022. As patients we *possibly* have enough knowledge to understand some of its meaning. Maybe not. I hope it's helpful to someone!

"For patients with substantial daily symptoms and frequent exacerbations (three or more per year), additional therapies may be required to improve quality of life and prevent further lung damage. In a meta-analysis of three randomized trials, investigators found that the use of macrolide antibiotics reduced the frequency of exacerbations and increased the time until the next exacerbation. Improvements in quality of life were also documented in those trials. The mechanism of action is unclear, although macrolides may inhibit quorum sensing by P. aeruginosa. The usual dosing regimen is azithromycin at a dose of 500 mg three times per week or 250 mg daily. Although the studies were conducted for only 1 year, it seems that macrolides are generally safe and have an acceptable side-effect profile over longer durations. However, caution must be observed when prescribing macrolides, given the risk of resistance and gastrointestinal, cardiac, and auditory side effects. Macrolide monotherapy should not be used when nontuberculous mycobacterial infection is present or has not yet been ruled out."