i had 1 prolia shot last november and the side effects were so bad. the day after taking the shot i woke up in severe pain could not close my hands and had diffulty walking and just getting dressed to go back to my dr. i suffered for months with the unending pain 2 compression fratures to date and discovered i had ra. no one in my family had ra ever i am 80 yrs old and until i got the prolia shot had no symptoms whatsoever. after shot i also had swelling of my ankels feet and lower legs, my dr put me on prednisone which helped and had bloodwork done and said i have 2 markers for ra. am now being treated for ra. it seems i got the shot went to bed got up the next day and my entire world was upside down. i can't say for sure the prolia shot did this but it sure is strsnge that before the shot i was fine. i also have osteoprosis and that is what started thids entire thing. these medications are maybe good for some but for othes tsking the wrong one is life changing. believe me i know i get up everyday in pain. when i asked my dr if it wee possible the prolia started something that may have laid dorment in my body for yrs his answer was could b don't really know. these drugs suppress the immune system and just maybe allow something that the immune system was taking care of to flare up i will never know but i do know the day before i got that shot i was fine. it is very depressing to me as i go over as to why i took the shot inmthe first place. my cousin and 2 friends have severe osteroprosis like me nd take no druugs and they are just fine. i thing i was scared into doing this which was wrong snd should hsve been given all the facts. i also blame myself for not checking it out and just saying yes. this i will have to deal with and live with everday for the rest of my life so please be careful it is hard to choose because if you make a mistake in taking the wrong one the consequences can be dire.