I am on methotrexate as I try to taper down the prednisone. 25mg meth right now a week and down to 7mg prednisone a day. I was diagnosed with pmr last December. Yes some side effectswith meth. Headache, nausea, fatigue for about a day. One day. Now at 8 months on methotrexate and the side effects are minor. Still have an off day but it’s improved every month. Worth it to get off prednisone. I’ll have to stay on meth for awhile.