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Transdermal HRT

Osteoporosis & Bone Health | Last Active: 29 minutes ago | Replies (114)

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@teb

I completely agree with your thinking! There are risks to every drug option and I'd rather take the risk with something my body naturally recognizes and offers so many additional benefits aside from bone density maintenance.

That is a super-low dose of estradiol you are on. I didn't even think it was offered at such a low dose. The doses I have seen listed that are helpful to bone start at .025 and I thought that was the lowest dose offered. I've been on .025 transdermal for about 5 years. I've mostly maintained my density (same overall dexa score) with a couple of vertebrae that show loss so that concerns me a little. I've recently seen an integrative gynecologist who is bumping me up to .037, a very small increase. She would definitely go higher but I'm concerned about the potential of increase in breast size. If you are considering increasing your dose (after your course of Forteo sounds like a good plan), it might be a good idea to assess your stroke/CVD risk if that is a concern. I've had my detailed cholesterol numbers done which most doctors don't order. If you ask for them, they might. I've tested LPa (genetic marker and hard to lower. fortunately mine was low), oxidized LDL (whether your particles are small and dense which tend to clump and form plaque), and a CT scan to determine calcium score. My calcium score was 0 which means there was no discernible plaque detected in my arteries as of yet. I'm tweaking a couple of things to try and keep it that way but since my risk appears to be low, I'm comfortable with continuing on the HRT and increasing my dose. Unfortunately, most doctors don't do detailed cholesterol bloodwork to really get a good determination of risks so it's important to ask.

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Replies to "I completely agree with your thinking! There are risks to every drug option and I'd rather..."

Thank you for sharing. Aside from your concern regarding breast size, did your gyn discuss risks of upping your dosage higher than .037?

This is great information. Thank you for sharing! I will bring this up with the OB/GYN specialist at Georgetown in December! Yes, I'm on the lowest dose of transdermal HRT. Mine is 14 mcg (I think I mispoke).

@teb we communicated in another thread about HRT, your experience is very positive one! I have a few more questions to ask you if you don't mind.

The results from most current studies are very supportive for HRT usage for womens general health. And if any of us are lucky, we'd get bone preserving effect from HRT just like you do! As you and other commentors pointed out, blood clots incidences were reduced to minimum by using transdermal; potential risk of uterus hyperplasia/cancer is dealt with using prometrium. From what I understood, breast cancer risk in estradiol + progesterone group has about 1 in 1000 absolute risk increase, is that what you had read? Whats your understanding of HRT on cvd risk? Are they (researchers) looking at clots related or lipid/plaque related cvd incidences (maybe both?)?

During HRT usage, what do your doctors monitor to minimize unwanted consequences?

Last but not least, when did you commence HRT after forteo therapy? I wonder it would take a while for HRT to reach steady state in blood and to be fully effective. Do you get your bone marker(s) monitored while on HRT? If you do, what kind of pattern are you and your doctor looking for to ensure HRT therapy is working?

I'm not in a hurry to know all these or to make a decision, so take your time if you could reply. Sorry this is a long list of questions. Thank you very much in advance!