I’m familiar with Cytoxin and Rituxin. What will you replace them with? Is your scleroderma controlled now? I was treated with Benlysta for five years but kept having infusion reactions so was taken off it. I was then prescribed Methotrexate which gave me sores in my mouth and nose. It’s been quite a ride. I love my doctor so won’t be changing him, just meds. I may suggest the injectible form of Benlysta. I felt the best when I was on that, minus the infusion reactions.