I'm so sorry that your hub is having such strong reactions to this regimen. Might it be worthwhile to ask for a break of one or two weeks before the next infusion? (I don't know whether his onc. would consider that OK or ill-advised.)

With regard to how I feel now, at an almost-three-month remove from my final (8th) infusion: I'm not thrilled about what seems to be peripheral neuropathy in my fingertips and toes, but if that's the price I have to pay for being better, then it's definitely worth it, even if the p.n. is permanent. (I don't yet know whether I'm better. I had my Whipple on 10-5-23, and it looks like radiation and more chemo are in my future; I'll know more after 11-9-23, when I next see my onc.)

If I have to resume Folfirinox and if the side effects are more intense and longer-lasting, I'll still consider it worthwhile *if* that gives me more time. (I'm 61 and bc there's longevity on both sides of my family, pre-diagnosis I naively/stupidly hadn't considered that I wouldn't see 85 or 75 or even 65).

One thing I forgot to note: On Day 5 of my final infusion (with Days 5 and 6 always being my worst), I experienced what seems to have been vasovagal syncope (I blacked out once when I got out of bed to use the bathroom). Dehydration was either the cause or *a* cause, so you're very smart to make sure that your hub is getting IV fluids when the pump is de-accessed.

Also, I remember feeling so bad in the aftermath of the final infusion that I thought, "I can't go through this anymore -- it's too much." But the side effects *do* end and people *do* return to more or less normal; it can be hard to have that perspective while feeling awful, and it sounds as though your hub is feeling deeply awful. I wonder whether pancan.org or the NPF might have resources about how people cope with extreme side effects -- ?

I fervently hope that your hub has good results in the long run; it pains me that this has been so hard for him (and for you), and I wish you both well.