I am not sure I understand your question. To bring up sputum we use a nebulizer system with hypertonic saline and sometimes other prescribed things like levalbuterol. After that nebulized treatment you use the Aerobika to bring up the mucus to a greater extent. You need to do both. They can also be done at the same time by attaching the Aerobika to the nebulizer cup. Nebulizer system means the cup and the compressor and tube. But some people use a hand held mesh nebulizer. My understanding is that those types are not generally good to use with the hypertonic saline. They will rust or clog or some such thing. Hope this is clear and helps?