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Hand and Foot Syndrome - any suggestions?
Cancer: Managing Symptoms | Last Active: Aug 25, 2025 | Replies (23)Comment receiving replies
@mosk I believe you may referring to a side effect known as hand-foot syndrome (HFS). HFS is side-effect of some chemotherapy types. It is also called Palmar-Plantar Erythrodysesthesia or PPE. It affects the skin on your hands and the bottom of your feet. It usually starts with tingling or swelling of your skin and can become painful, red and numb.
I moved your question to this related discussion where members like @sallyg @adanab @seathink @mjjc are talking about hand and foot syndrome.
- Hand and Foot Syndrome - any suggestions?
https://connect.mayoclinic.org/discussion/handfoot-syndrome-any-suggestions/
Have you finished chemotherapy treatments? What chemo were/are you getting?
Replies to "@mosk I believe you may referring to a side effect known as hand-foot syndrome (HFS). HFS..."
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The chemo that I got was Folfox 6, which includes 5-FU. The last treatment of 12 was 2 months ago. The situation with the skin on my hands and feet is only getting worse so far. I met with the oncologist today who said it's a very typical side effect of this type of chemo and with time it'll get better. Hopefully so and hopefully soon.
It does sound very much like HFS. This is the first time I'm hearing about this and did some research on it. Makes a lot of sense. I'll see what others share about this.
Thanks so much for responding. This is so helpful.