A person suffering from depression of course isolated more and more each time they slip deeper. I was in an abusive relationship for years the ending of it is when the depression but the hardest, it lasted 38 years. I struggle with it everyday , now my son who has always had issues , depression , bipolar disorder has come out of a 4 year marriage , she took there kids and started a new life with an much older man. How sad. He too withdraws from life. All people who suffer mental health suffer greatly , they don't want to hurt anyone but they usually do , the ones that they are closest too.