Anyone taken Xeloda for a long period of time: Side effects?

Posted by leesburger @jseim106, May 6, 2015

I was diagnosed with Stage I colorectal 3/12, Had surgeries and chemo, and was declared NED. Then 12/13 it was back, Stage IV, mets to lung and liver. I've had chemo again and am now NED (Thank God), but am on Xeloda, and have been told it was for the rest of my life. I also take Chinese herbs and IV Vitamin C, so don't really know what has helped. I'm currently taking Xeloda, one week on, one week off : 1000mg BID.

Has anyone else taken Xeloda for a long period of time, and if so, what are the long term side effects. I have painful neuropathy in my feet and would like it to go away!

Thanks for all your help and support (I'm open to any questions about my journey & tricks that I believe have helped me)

Interested in more discussions like this? Go to the Colorectal Cancer Support Group.

billbills | @daledales | Oct 21, 2023

In reply to @rigal "Sue l, I’m on 2000 mg of xeloda daily for MBC and experience the hand foot..." + (show)

for feet neuropathy, I am taking pregabalin ( lyrica) x 2 per day (75 mg) , I have meaningful reduction in numbness and shooting pains, I will have a meaningful increase in numbness if I skip a dose

mustang08 | @mustang08 | Oct 22, 2023

My husband has irreversible chemo induced neuropathy which started as a side effect of oxiliplatin. He takes Xeloda 3000mg a day. Gabapentin plus cymbalta plus over the counter Nerve Renew (b vitamins) has controlled it fairly well. Stage IV rectal cancer with liver metastasis. 20% urea cream helped with skin cracking and peeling. But the disease is stable after 16 mos so that’s good.