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brighterdays (@brighterdays)

Zometa, ONJ, when is it really necessary?

Breast Cancer | Last Active: Oct 22, 2023 | Replies (11)

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@semurrey

Thanks for this link! I am so scared to go on bisphosphonates as I have significant TMJ with one disc totally eroded due to clenching. I wear a very expensive mouthguard nightly which helps but at 58 yrs old and needing a few crowns, filings replaced I dread the side effects of these drugs. My doc only mentioned it would help me alleviate risk of curvature, hunch back from letrozole estrogen depletion, etc. I'm only 8 months into Letrozole but know it will get worse. Maybe I can avoid curvature ?? She didn't mention anything related to bones mets. Any advice?

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Replies to "Thanks for this link! I am so scared to go on bisphosphonates as I have significant..."

Curvature comes from fractures resulting in lower bone density. What are your DEXA scores?

I did 5 years of letrozole and my docs did not want me on Reclast or Zometa (same med) due to other health issues. I already had pretty severe osteoporosis when I started, and three old fractures from a traumatic fall.

I did lose bone density and due to COVID was late in starting Tymlos, a bone-builder and did have some lumbar fractures.

But Tymlos has returned my bone density to pre- cancer levels in two years of treatment.

So one option is to monitor your bone density and do Tymlos later. One caution: Just as with menopause, I lost maybe 10% bone density when I started letrozole but then it levelled off.