I have tried Miralax, Dulcilax, stool softeners, drinking more water (although now I can't because of a major issue with low blood sodium). Nothing has helped. Phillips Milk of Magnesia helps a little bit takes a long time to work! I even take Betaine HCL with Pepsin to help metabolize my food since my sigmoid colon was taken. I've had issues my whole life. I have recently used a Fleet liquid glycerin suppository (a little plastic bottle) which worked OK. But went to Gastro doctor this week as I'm really concerned with "lack of movement" and was given Motegrity (prucalopride) and took it yesterday at 2:30 pm and by 5 pm I was on the phone with his office having just had a bowel movement that was not forceful or explosive but emptied me!! I'm hoping now that I'm cleared out I won't be having such bad problems anymore. I will not rely on pills or meds to help me go other then once in a while. Just as information, I have always found taking laxatives dehydrated me, thus making my condition worse!