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@cwal

I have not been able to pinpoint a common thread or cause for an exacerbation. I have no history of asthma or other lung disease other than MAC. I have experienced 2 exacerbations in a span of 5 months. None prior to that. Those 2 were quite harsh and I still have been unable to regain my weight from the last one. I'm thinking I am over the wait and watch and go ahead and try the treatment although that is scary.

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Replies to "I have not been able to pinpoint a common thread or cause for an exacerbation. I..."

I guess that 2 exacerbations so close together would make me start thinking about antibiotics too. What does your pulmonologist recommend?
Does your latest CT show progression of the infection compared to the previous one? Or the latest sputum sample show a higher level of infection? Those would be 2 keys for me.

But, I would try really hard to put on some weight first - a dietician can help you design a really high calorie meal plan, and a way to continue it during treatment. I lost 20% of my body weight in 18 months on the antibiotics, in spite of forcing myself to eat something high-calorie & nutrient dense every 1-2 hours during treatment.

How long have you been on "watch and wait"?
Sue