Yes! It seemed to take about a week for the before and after became noticeable, but my husband, stage 4 inoperable pancreatic cancer, no longer takes any pain medication. I must Tell you, however, that all through Folfirinox and radiation treatments, he never had pain. Pain only started about 2 1/2 months after stopping all treatment because he didn’t want any more chemo. Then he took 2 Hydrocodones every 6 hours with Ibuprofen for breakthrough pain. After the plexus block, he has no pain. He is, however, now in home hospice for about two weeks , for a week now everything has gone downhill, he can no longer leave his bed and no longer eats. He will probably leave us in the next few days, but he has no pain.