HI, Yes, it's 3 X a day, every 8 hours, and it takes about an hour to drip through. I had a home health nurse come and set me up and show me how to do it. It's been OK to do, except I'm sleep deprived having to wait until 10 p.m. to infuse and don't get to bed before 11 p. I'm used to going to bed at 9:30! I take a nap during the day if I can, but you know how that goes. The infusing wasn't new to me as I did that for 4 months 9 years ago when I had MAC and Nocardia...then stayed on other oral antibiotics for 18 months. I haven't really gotten any side effects from the Meropenen. Yes, I have a PICC line in my upper arm as I did before. They put that in at the hospital. I don't know how/if I'll tolerate the Toby but I hope so. The other thing that is happening is I am really getting edema in my legs/ankles etc. I don't know if the extra saline nebs are doing it or from months of little activity. I'm trying to be more active now. Take care and hope you feel better. The Meropenen is helping me but this is a long term deal isn't it? I never even heard of pseudomonas! Darn...