I was on Linzess highest dose for about 3 months. I lost too much weight and stopped, now trying to manage with OTC. But my Linzess protocol might help. I kept my dosage in fridge, read somewhere that helps it retain potency. I would take first thing in morning after waking, and would drink 20 ounces of water with lemon..an hour after taking med, would eat breakfast - yogurt, boiled egg, something soft. Would also drink another 20 ounces of cold, lemon infused water. This protocol worked well every morning. Also, walking every morning helps. Cleaned out each morning. Worked, but I lost too much weight.

Hi, so how are you feeling recently??