Hi, I, too, have constipation issues. My GI said it was IBSC, and put me on Linzess 290mcg. , highest dose. But that stopped working. I still take it along with this regimen: Oh and stool softeners don't help with constipation. So, I alternate every day; Linzess with milk of magnesia (double dose)
Linzess with Dulcolax (bisacodyl) tablets (double dose)
Linzess with Citrate of magnesium (whole bottle)
Linzess with senna tablets (double dose)
And bisacodyl suppositories when needed.
Also, I take a probiotic with prebiotic, and digestive enzymes. I like the pineapple and papaya ones in capsules. You take those with food. Yogurt is best for it's digestive properties.
Your body gets used to anything you take daily, so I have been feeling much better. I hope this helps you.