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Pancreatic cancer relapse

Pancreatic Cancer | Last Active: Nov 1, 2023 | Replies (69)

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@wheatley

I initially went thru 12 FOLFIRINOX , the last one w/o oxaliplatin. About 6 months later went back on FOLFIRINOX w/o ox. Have had 10 treatments. Side effects are manageable but can anyone tell me what I am missing by not having ox as p/o my treatment?

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Replies to "I initially went thru 12 FOLFIRINOX , the last one w/o oxaliplatin. About 6 months later..."

@wheatley , "can anyone tell me what I am missing by not having ox as p/o my treatment?"

I assume/hope you're "missing" the neuropathy and cold sensitivity, but not really missing it. 😉

My knowledge is very limited in this area, but my understanding of platinum agents in general (carboplatin, oxaliplatin, cisplatin) is that they help damage cancer cell DNA and its ability to repair itself, which may provide extra benefit to patients with mutations (like ATM) that hinder DNA damage repair. If you have related mutations (PALB2, BRCA, ATM) you might benefit from platinum. If you haven't had the genetic tests to identify mutations, you should ask your oncologist about those. It's one of the doorways that might open up appropriate clinical trials.

As Forrest Gump said, "That's all I know about that."