PPI use and side effects

Posted by mikejjb123 @mikejjb123, Sep 20, 2022

My doctor told me to take dexlansoprazole in the morning for chronic nausea when nothing else worked. Well, not so nauseas as before, but now have a bad acid taste in mouth all day long. Not seeing dr for another month. Any ideas or suggestions. Was taking pepcid twice a day but now only at night. Thanks.

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Profile picture for seapen @seapen

A side effect of Omeprazole is diarrhea. A side effect of Rabeprazole is gas. What pre/probiotic would your suggest taking to combat these symptoms? Or would it be better to take something else for acid reflux?

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Not a rant to me. Thank you for the information. When I complained to my GP doctor about gas, he said that flatulance is not a medical problem and I should get a dog to blame for the odor. I have heard so many bad stories. The ppi instructions say to take them for 2 weeks. I am on my second year and my doc says to keep taking them. Ugh! Thank you for sharing your experience.

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Profile picture for rozy288 @rozy288

Just google functional medicine Drs ( or APRN ) some Chiropractors are them too like mine .
Or Naturopathic type Dr.
( more holistic).
Keep us posted .

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Thank you.

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Profile picture for billgil @billgil

Hello; I have been on PPIs [Rabaprozole [20mgs 2x per day]] for over a year now and they work well for GERD with no side effects, YET. I know about the long term effects but they work for me. [H2 blockers don't] so I have little choice other than the surgery "Funduplication" which I would like to avoid. I Have tried Diet change to no avail.However for the last 2 weeks I have experienced a continuos chronic stomach ache, mild most of the time but is now becoming more intense. No other symptoms just general belly ache. From your experience has anyone else found this be a side effect of long term PPI use? or something else? Doc appt in a week. Thanks

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I have been on PPIs for 2 years with no side effects so far and they are working for me, and yes I am aware of the long term side effects but I cannot get off. I have tried to no avail.
I am now experiencing heart issues [Arrhythmias]. I am 75 so not too unexpected ,,, but I have now come across these two studies on Arrhythmias and PPis,
Has anyone else experienced this?
https://www.innovationsincrm.com/cardiac-rhythm-management/2010/december/29-proton-pump-inhibitors-focal-arrhythmias#:~:text=PPI%20use%20is%20associated%20with%20focal%20arrhythmias.
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1031&context=cph_etds#:~:text=Proton%20pump%20inhibitors%20(PPIs)%20are,that%20PPIs%20may%20be%20proarrhythmic.

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Profile picture for wgilm @wgilm

I have been on PPIs for 2 years with no side effects so far and they are working for me, and yes I am aware of the long term side effects but I cannot get off. I have tried to no avail.
I am now experiencing heart issues [Arrhythmias]. I am 75 so not too unexpected ,,, but I have now come across these two studies on Arrhythmias and PPis,
Has anyone else experienced this?
https://www.innovationsincrm.com/cardiac-rhythm-management/2010/december/29-proton-pump-inhibitors-focal-arrhythmias#:~:text=PPI%20use%20is%20associated%20with%20focal%20arrhythmias.
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1031&context=cph_etds#:~:text=Proton%20pump%20inhibitors%20(PPIs)%20are,that%20PPIs%20may%20be%20proarrhythmic.

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I was suffering arrhythmias which caused dizzy spells and blacking out, I was in and out of the emergency room, had stress test, heart ultra sound and a 24 hour Holter monitor which showed that my heart had stopped 4 times over the 24 hours, they put me on beta blockers and it did no good. Then I tried apple cider vinegar 1 TBS, and blackstrap molasses 1 TBS in a half glass of water once a day and the dizzy spells stopped. Now I'm fine as long as I keep up the ACV and molasses, when I forget he dizzy spells return. It might be worth a try for you.

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Profile picture for wgilm @wgilm

I have been on PPIs for 2 years with no side effects so far and they are working for me, and yes I am aware of the long term side effects but I cannot get off. I have tried to no avail.
I am now experiencing heart issues [Arrhythmias]. I am 75 so not too unexpected ,,, but I have now come across these two studies on Arrhythmias and PPis,
Has anyone else experienced this?
https://www.innovationsincrm.com/cardiac-rhythm-management/2010/december/29-proton-pump-inhibitors-focal-arrhythmias#:~:text=PPI%20use%20is%20associated%20with%20focal%20arrhythmias.
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1031&context=cph_etds#:~:text=Proton%20pump%20inhibitors%20(PPIs)%20are,that%20PPIs%20may%20be%20proarrhythmic.

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Did you try to get off the PPI gradually? If you stop quickly you'll have an acid surge. I was on a PPI in the AM and famotidine at night and I wasn't feeling great so I decided to try to wean off the PPI. In the end I stopped both and now I feel better than I felt when I was taking them.
What I did was I gradually replaced the PPI with an H2 blocker (famotidine), for example, by taking the famotidine once a week instead of the PPI, and then twice a week, etc. After that, I was able to also get off the famotidine. There's much less of a problem to stop using famotidine. Even if you have to continue taking famotidine or the like, it's better than taking the PPI long term, which also seems to have other long term problems.

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Profile picture for bosco17 @bosco17

Ive been on 40mg of Pantoprzole for 4 weeks and my RBC count, Hemoglobin,Iron, Hematocrit have gone abnormal. Anyone else having these types problems?

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I’m 57 with osteoporosis and Barrett’s esophagus are ppi the cause of this

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Profile picture for brownstar57 @brownstar57

I’m 57 with osteoporosis and Barrett’s esophagus are ppi the cause of this

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Hi,
I know that Omeprazole is linked to Barrett's. It is now under investigation by US FDA for other affects of long term use.
The panic was on when I was diagnosed with Barrett's, but I'm fortunate to be able to prove my throat problems predates my starting Omeprazole, which I have been using since 2013.
Cheers

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Profile picture for brownstar57 @brownstar57

I’m 57 with osteoporosis and Barrett’s esophagus are ppi the cause of this

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PPI's can cause osteoporosis, but so can other factors. See an endocrinologist for the osteoporosis.
The PPI is usually given to treat Barrett's esophagus, so you should explain a bit more about your history. Don't ignore the Barrett's. See also other lifestyle changes you can make to treat the acid reflux which causes the Barrett's

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Profile picture for brownstar57 @brownstar57

I’m 57 with osteoporosis and Barrett’s esophagus are ppi the cause of this

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PPIs do not cause Barrett’s. They are used to reduce reflux so that Barrett’s might not progress, or to eliminate reflux if you have had ablation for long segment or high dysplasia.

Prolonged use of PPIs (years) may make you prone to osteoporosis, but it is a small risk worth taking if you have Barrett’s with high dysplasia.

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