I have and they didn't have a really good answer. I am in stage 3 so I'm still not feeling to many of the affects yet. Just the normal pain in the flanks and sides. I have 10cm cysts on each kidney that are causing some pain, and not allowing me to sleep comfortably anymore. I started Jynarque and was a year into thing it. Had to go off as I had to have surgery(not related to pkd). I see my Nephrologist in a couple weeks and will be back on it. At Mayo next week though as they are the best. Hopefully a few better answers and possible a little relief. Thanks for reaching out.