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Zometa, ONJ, when is it really necessary?

Breast Cancer | Last Active: Apr 28 12:57pm | Replies (24)
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@windyshores

I would be curious to see any studies that show Zometa (or Reclast) can help prevent metastasis to the bones.

I had pretty severe osteoporosis before starting my 5 years of letrozole and lost a good amount of bone density because my docs did not want to put me on Reclast (same med as Zometa) due to afib, which has since proven not to be a concern.

I went on Tymlos and regained all that I lost and more. After two years of Tymlos, 9 years out from cancer diagnosis, I am now going on Reclast!

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Replies to "I would be curious to see any studies that show Zometa (or Reclast) can help prevent..."
brighterdays | @brighterdays | Oct 19, 2023

Here is a meta analysis of Bisphosphonates
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60908-4/fulltext

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talldutchy | @talldutchy | Apr 17 10:00am

I was diagnosed with MBC in my sternum ( destroying the bone) , liver, lymph nodes in Jan '24
On Letrozole and palbociclib.
Last week got my 1st infusion of Zometa....48 hrs later BOOM, both knees ( with osteoarthritis) blew up to double in size and I could not walk! They prescribed pain medication over the phone, they couldn't believe this was caused by Zometa!
Today is my 3rd day since getting around in a rented wheel chair and I can now get up from a chair without hubby's help. Still very swollen knees that can't straighten out yet. I'm very hesitant to try Zometa again in 3 months. Did anyone else have a strong reaction to Zometa?

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