@anindita , I don't have time now to type it all out eloquently, so, as someone who experienced a recurrence very shortly after a "perfect" surgery, I'll just cheat by referring you to my 10/8/2023 reply to @gamaryanne on this thread: https://connect.mayoclinic.org/discussion/mrna-vaccine-trials/ . I'm also pasting the same attachment to this thread.

I encourage you, at a minimum, to do LOTs of frequent follow-up CA19-9 testing after your Whipple, in addition to imaging and ctDNA tests like Signatera, PLUS chemo and/or radiation.

I can't say how effective the post-op chemo is, but I can tell you how ineffective the lack of it is. (I went from clean to Stage-4 in the blink of an eye.)