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Axonal peripheral neuropathy: Finally, a diagnosis!
Neuropathy | Last Active: Nov 3, 2023 | Replies (115)Comment receiving replies
Multiple case series have demonstrated the emergence of small fiber neuropathy following acute coronavirus disease 2019 (COVID-19) infections. Further, one large case supports that the COVID-19 vaccine has been reported to result in small fiber neuropathy. We report a case of a patient with confirmed small fiber neuropathy post-COVID-19 vaccination with positive FGFR3 antibodies. Although the COVID-19 vaccination has helped protect many against the COVID-19 virus, the vaccine has been associated with some complications. There are published patient cases of COVID-19 infection and Pfizer and Moderna vaccine administration causing neurological conditions including Guillain-Barre syndrome, transverse myelitis, and small fiber neuropathy [1–8]. The mechanism underlying the development of small fiber neuropathy after COVID-19 vaccination is not known. Therefore, effective treatment remains unclear. It is suspected that small fiber neuropathy occurring after administration of the COVID-19 vaccine could be an immune-mediated process [4
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There is strong epidemiological data suggesting that COVID vaccination can cause neuropathies such as Guillain-Barre syndrome [6]. Small fiber neuropathy, unlike Guillain-Barre syndrome and chronic inflammatory polyneuropathy, is not an established post-inflammatory or autoimmune condition [12] nor is it an FDA-approved condition for IVIG. This is particularly relevant since many patients have suffered with idiopathic small fiber neuropathies and can only be treated palliatively with non-narcotic nerve pain medication.