I’ve had PMR for a year. I’ve been on prednisone since diagnosis. Tried methotrexate for 6 mos & couldn’t notice any difference. And the side effects were not fun to deal w either. My rheumatologist said that inflammation is bad for your body too & prednisone reduces the inflammation (& pain). Is taking prednisone the lesser of the 2 evils? It’s hard to make that determination but I’d like to not be in pain & be able to function better. So, alas, I continue taking the prednisone.