I am 69 and have celiac (HLA-DQ8), collagenous colitis (IBD), hypothyroid, MGUS, and had reactive arthritis (HLA-B27) 33 years ago. The range for "normal" TSH (thyroid stimulating hormone) is between about 0.4 and 5. I just increased to 88 mcg synthoid/day because my hypothyroid symptoms were so irksome, such as weight gain (even tho I bike ~7000 mi/year, with no snacks, low sugar/salt and minimal processed foods, GF, etc); severe constipation, and being tired. Metabolism slows if my TSH numbers get higher than about 1.5. Everyone is different, but I do best with levels near 0.4. It is important not to be in hyperthyroid range. I've been hypothyroid for +20 years and my metabolism is best for me with higher doses of synthoid. Doctors early in my diagnosis had me at TSH levels close to 5 and that was extreme lethargy and weight gain. BTW, I've had celiac for 14 years, but likely have been subclinical or gluten intolerant my whole adult life because of symptoms that went away after GF, such as skin rashes, GI problems, reflux, and feeling tired. I sometimes wonder if I went GF 50 years ago if I would have fewer autoimmune diseases now.