Has anyone taken Lynparza?

@elizabethboie - thank you for your response - what was your dx and what was your dosage? As mentioned I'm TNBC BRCA 2+ and have completed my chemo, surgery and radiation.

I am new here; I have been on a different side for a while. Simply, I ended up with Pancytopenia after 13 rounds of chemo and it continued with a version of the Olaparib pill that i was told was a cousin of Lynparza. This was December of 2021. In Feb i had surgery. I must add I was diagnosed with BRCA2+ in August of 2021. Come June of 2022, I was on Lynparza for 1 year. I was only stage 2, but I was Brca2 and Her2+. Er+/Pr-. My MO doctor felt this was a good choice. 200mg am and pm. 1/3 less than the 29 day pill i had in ecember. All in all, I was on Herceptin/Perjeta infusions for 18 rounds during this time. After each end side effects lessened. Joint aches, and neuropathy. Lynparza is a chemo pill, but no more hair loss. In all, my white cells remain low and platelets too. One great thing, the metal taste is gone.

Hi @katgob, your experiences are helpful. How did you find Mayo Clinic Connect?

I have regularly been on breastcancer.org, as a friend suggested I join after my diagnosis, As my active treatment ended, I was looking up Ovarian cancer as my sister was diagnosed in July. I was finding many studies put out by the Mayo Clinic that were interesting. I saw I could join and decided to do it. A friend of mine is being treated at MD Anderson in Texas, another sister at Roswell Park in NY and Cleveland Clinic.
I am being treated at the City of Hope in Duarte.
I have found in Mayo connect an interesting mix of info. I do not have to be treated at Mayo to get a benefit from hearing from others and sharing with others as time allows.

I was on Lynparza from June of 2022 and June of 2023. I had the same dosage as BPknitter.
Side effects? I was also given 18 infusions of Herceptin/Perjeta during this same time from March-March. I had the genetic test and had Brca2. My tumor was HER+. My Medical oncologist and the team at City of Hope gave me Lynparza as my 16 rounds of chemo were shortened to 13 rounds due to side effects.
So, for side effects I had an ongoing slight metal taste in my mouth till a few weeks after my last Lynparza pill. Neuropathy in my fingers continued. Honestly though, I had breast surgery in Feb and Dec of 2022 and I know those as well as the meds combined for the joint, shoulder and trigger finger. Most of those side effects are negligible now. How did the drug help me? Time will tell.

I've been on Lynparza now for just about two months - my only side effect appears to have been when taking the pills on an empty stomach. I had a short bout of the runs when taking the pills early in the morning on an empty stomach. Started eating before taking the pills and now I'm good, I can actually take the pills with food and still be good so I've changed the time I take the pills. I'm getting ready to have my first dr. visit with lab work after starting the pills - so we'll see what numbers I have. My dosage might get increased as I believe I'm on the lowest dosage prescribed. I'll update after my dr. appt which is next week.

I look forward to hearing. I was on 3 drugs for most time i was on Lynparza. Side effects lessened after I got off each.

Has anyone had increased ALT SGPT (which I think has to do with liver process)? I'm on Lynparza 100mg twice a day for TNBC BRCA2+. I've been taking the pill since July 2023 and believe I'm only going to be on a few more months. Previous lab work had the ALT SGPT within normal ranges, it's started creeping up and is just above normal range. I'll check with dr. (see her tomorrow) to see if level is still within OK range and will it recover after I'm off the pills.

Just wanted to see if anyone else experienced elevated lab results and if subsequent lab results showed recovery of the ALT SGPT test.

I did not have that result. Just yesterday I had my first day of conditioning for my bone marrow transplant. We talked Lynparza. I finished it after 1 year in mid-June of 2023, He said my white cells and plantlets have still not reset. They continue going down. That is not an effect of Lynparza. It is the underlying TP53 mutation.
I do think checking with your DR is perfect. Keep us posted bpknitter53.

Met with oncologist yesterday, SGPT levels are rising; but not at dangerous levels. I'll only be on the meds until the end of the year so she believes I should be fine. But we'll keep an eye on the levels. But all other lab levels were within normal levels - so I'm good.