I’m really new at this I can only tell you that I have been on these patches for going on 3 weeks. I put one on and it helped me with detox from the Oxycodone. I was on Oxycodone for about one and a half years. My doctor prescribed an anti depressant along with the patch and so far I’m pain free for the most part. I have felt low energy a little rushing noise in the ears, I also have a little balance issue when I stand up in the morning. My lungs have cleared up compared to what the Oxycodone did to me. I’m very happy so far and I would just suggest if you want to try it get with your Doctor and see what they think.