In my case it meant that cancer was left on the margin and remains where the urethra was connected to the bladder. I have been very fortunate in that it has taken 24 years to reach the point where I have started Orgovyx. I had a radical perineal prostatectomy in August 1999 with a preop PSA of 2.6. My PSA went to near zero (.05) after surgery. PSA started slowly rising and I was diagnosed with a recurrence in 2007. It was recommended that I have radiation to treat the recurrence. I had 35 treatments over 7 weeks and my PSA once again went to near zero. However, it once again starting rising, but very slowly, until it doubled in one year (Jan 2022-Feb 2023). My Mayo oncologist recommended that I start hormone therapy which I rejected. In March I moved to Rome, GA and engaged with the Harbin Cancer Center. I had consultations with a Medical Oncologist and a Radiation Oncologist> My PSA was then 3.62, higher than it had ever been. Bothe Oncologists said that if I did not do something to lower my PSA the cancer was certain to metastasize. That was a wake up call. I started on Orgovxy on September 6. I had my first follow-up visit this week and my PSA dropped from 3.62 to 0.42. My testosterone also dropped from 185 to 3, that of a 50> woman. The most bothersome side effect has been hot flashes that occur throughout the day. I hope this gives some insight when making decisions. I probably postponed starting hormone treatment longer than i should have.