I was due for 2nd Prolia shot on 10/6. I saw my endo in September and we both agreed that I should discontinue this medication. So, we're just going to monitor things and no more meds for now. I also have autoimmune problems...maybe that's why I had such an extreme reaction. I have many friends that have taken prolia for years with no problem. Everybody is truly different and unfortunately there is no one size fits all. I wish you the very best in your search for bone health.