All I can say is that I have been there and recently made the decision originally offered by my GP to go with Fosamax (alendronate) after I went through the Cochrane reviews website and PubMed and read tons of articles on my own (as an academic health professional of a different sort). The alendronate has the longest track record and yes, side effects, but they all do and getting a twice annual shot of something powerful is also a scary proposition. We are in a situation where science just isn't there yet with the best options for Osteoporosis. 50 years from now, if science can continue, they will be raising their hands in horror at what we were told to do now. I have decided to accept that because life happens and we all get old and only so much can be done. I have no idea if I will tolerate Fosamax longer-term but at least the first pill had minimal side effects (weekly dose). Re supplements - so little known also and very confusing evidence. K2 has a good rep on social media but who can trust doctors on Instagram. There is even less science in the supplement industry. I was taking calcium regularly until I had a heart attack and found out I had blocked arteries (calcium collecting there!) so now I only get calcium through food and take magnesium and Vit D. K2 my cardiologist said she wouldn't argue against but really, we JUST DON'T KNOW THINGS. That is the bottom line....Two things that are making me happy are following Dr. Sherri Betz, physiotherapist, and Bones for Life. Exercise programs that help...no strong evidence that they harm or help but they are making me feel good and I hope to avoid those tiny spinal fractures by learning what NOT to do and what to do instead....one good thing about the Bones for Life is that the SUBMAXIMAL effort.....pushing ourselves is something we were taught early on to make advances in physical training..but we can cause repetitive strain injuries or even fractures now that the bones are decrepit...so thinking at a 20% effort level has been liberating and I feel better for those programs. NOT advertising them because they are not cheap or free but another place to go for free is Osteoporosis Canada. They have a good pamphlet you can download called Too Fit to Fracture. Hope this is of help and would like to hear other people's comments.