In keeping with this discussion, has anyone asked the Denver or Mayo doctors about the use of anticholinergics (sp?) with respect to bronchiectasis and making mucus harder to expel? Trelegy and spiriva (I think) both have some anticholinergic effect. Logically it has always seemed to me that drying up the mucus was not a good idea but I have no clue about this. I have an autoimmune disease and have to be on steroids (low dose). I also have asthma. Some of us need steroids for various reasons and have managed to survive for many years!! My assumption is there are various theories about these drugs none of which are the final word. For my allergies and post nasal drip I use a nasal spray Azelastine of which very little is absorbed by the body (allegedly) combined with a spray of a steroid like flonase. These are complicated issues.