When I use liquid Albuterol or Levalbuterol it’s about 10 minutes. The 7% saline takes 20 minutes with the breath activation turned off. I pause and huff cough every 5 to 10 minutes or when I feel mucus moving. FWIW I use it in the morning only and use a faster nebulizer in the evening. It is time consuming but I think this set up gets deeper in the lungs.