I only had nausea and some skin reaction so what you are seeing is quite unusual I would think. My son used patches too and only had the skin rash issues sometimes but with a cortisone cream it was fine. I am assuming it is for your chronic pain. My son moved to ketamine wafers and now no patches. Ketamine works for some people with chronic pain, and you can avoid the opioid impacts so many people suffer from. It was a game-changer for him - no more patch-related issues, no opioid side effects, and far less pain. The difficulty is finding that specialist to see if it works for you. For some people, it does not work, or the side effects are too much. We are all built differently. One trick we did learn is to take goat weed or milk thistle tablets which help keep your liver much happier. It is so frustrating when what helps becomes worse than the original issue.