GlaxoSmithKline purchased Biotene from those who originally formulated it some years ago. GSK has changed the formula since then. It no longer contains the enzymes that were in the formula after they purchased it. Previous owners of the brand, I am told, now offer what they call Salivea mouthwash, toothpaste, spray, pretty much the same formula which includes the enzymes GSK took out of the go-to Biotene dentists recommended previously. Most dentists even today seem to be unaware that the GSK Biotene is not the same as it was prior to GSK's purchase. I learned this quite by accident when Biotine did nothing for me. Salivea mouthwash helps me a lot, and their toothpaste, has no sodium lauryl phosphate (allergic to this) in it yet still has fluorde, has also helped.