I started out with CA 19-9 at 1750 and was advised borderline resectable. Took 10 treatments. When I finally had the surgery, the CA19-9 was in the normal range. There was no longer any viable tumor found. I have the BRCA gene and this tends to be more responsive to chemo. I had difficulty with the irinotecan, stopped after the first treatment. The rest was not so difficult. Since it was always the same thing, tended to be predictable as to how I would do after the treatment. I was treated on Tuesdays, I knew that I would feel a little queasy Thursday am when it was time to return the infusion pump so I took Compazine preventively. I knew that by Friday afternoon would be OK to go out if I needed to. It became predictable. I had some symptoms of neuropathy, minimal, but after stopping the neuropathy got worse. I feel the effects but it is manageable. Getting over surgery has been a very slow process, for a while it seemed nothing was getting better but after 6weeks I gradually turned the corner.