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Was your endometrial cancer tested for mutations in the gene POLE?

Gynecologic Cancers | Last Active: Apr 1 1:02pm | Replies (28)
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@jjevitts

Hi,
I was just wondering if anyone could explain the POLE testing and the effect in endometrial cancer? I was tested and found to be POLE negative, which is my understanding not the outcome you want. Does it effect the prognosis? Or recurrence?
I’d so appreciate any insight. I’ve read quite a bit, but it’s so technical. Thanks so much!

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Replies to "Hi, I was just wondering if anyone could explain the POLE testing and the effect in..."
Helen, Volunteer Mentor | @naturegirl5 | Oct 1, 2023

@jjevitts Hello, @val64 started a discussion on POLE testing. Some of your questions might be answered by reading this Discussion and responses.
https://connect.mayoclinic.org/discussion/testing-endometrial-cancer-for-mutations-in-the-gene-pole/
I’ve tagged @val64 as she is very knowledgeable about this and I’m hoping she will jump in here and provide you additional information.

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val64 | @val64 | Oct 1, 2023

POLE mutations are present in about 10 percent of endometrial cancers and and are associated with a good prognosis and a very low risk of recurrence. If the test had been positive, that would have been something to celebrate, but a negative result doesn't really change the outlook on your situation either positively or negatively. Let me know if that doesn't answer your question.

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