I know some people loose weight on it. It will give you more endogenous endorphins and feeling of full but not sick. I get the feeling of full. Are you doing sublingual drops or capsules. Naltrexone is soluble in water room temp. The fillers are minor. I take 52ml of water. Take the coating of and crush the pill and dilute it in water. I take 4.5ml with plastic syringe. It's an old biohack.