Frances 007, Hi. Regarding dropping down from 75mg EFFEXOR XR to 37.5 mg. This was done with ease * over 3 months or so. Compared with what was to follow. * I had no noticeable reactions, barring a short term (1 week) "step down" withdrawal jolts to my system, each time I dropped down to 37.5 . These reactions were short lived. The REAL issues, (as is commonly experienced by others), come when titrating down from 37.5 to zero. In fact, I was eventually **diluting individual beads from a 37.5 MG slow release capsule (3x beads in each) so, 3,2,1 beads. Then** syringing down in a diluted pot @ 10ml degradations , every 2 months 3,2,1 beads. This took 24 months. BUT, as someone else here has said. The withdrawal effects DO NOT STOP @ zero pill taking! No one knows , as it on a individual basis, as to how long the final , (after pill taking), withdrawal / side-effects issues will last. I have identified 3 to 5 years ! Also , the effects go away & come back over this period. Recent info I have secured , indicates about 50% of people have NO issues with EFFEXOR withdrawal and can even stop quite abruptly. But the rest are all over the place. Critically, as has been commented on here, it is the PACE of titration off that is key to mitigating these severe issues in the most sensitive of people. To stop @ 37.5 is not recommended.