@kathyyvette I am in a similar situation with drop from 53 to 36. But my Cystatin C is not so bad (50-54). My nephrologist goes by that because the creatinine eGFR is affected by things like losing muscle mass. My nephrologist wants me to hydrate and eat both salty things and protein to get my blood pressure up. She had me do an echo of my heart with the idea that weak heart function and low bp could be lowering the filtration rate. All okay. Then the idea that slight weight loss could be releasing muscle enzymes but test was negative. Still a mystery! I have stopped all pain meds except for Tylenol which is difficult! I have to have infused Reclast which can be damaging to kidneys. They are doing a 20% dose with IV hydration. Nervous!

@kathyyvette Welcome to Mayo Clinic Connect. As you read through the posts and different conversations here, you will see a comment we refer to often. That is, it is better to look at trends in blood test results, not single values. There are many factors that can affect results, including but not limited to: hydration level, recent exercise, medication changes, illness/infection, different labs processing the samples, fasting or non-fasting, other disease processes.

Maintaining a moderate exercise program, following a sound renal diet [low sodium/calcium/phosphorous, good protein], minimizing stress wherever you can, can go a long way to helping you keep your eGFR from slipping too rapidly.

Any further questions for me?
Ginger